Leucine powder is sold as a bodybuilding supplement, meant to be mixed with fluid and consumed twice daily, especially after a workout. Leucine is an amino acid more commonly found in branched-chain amino acid supplements, where it can work together with isoleucine and valine to prevent muscle breakdown during exercise and help stimulate muscle growth, leucine is also sold separately because it is broken down and absorbed faster than the other BCAAs. Whether it works as well in practice as it does in theory remains to be seen, however, and research is ongoing.
Leucine
Leucine stimulates muscle protein synthesis. Research suggests that this may happen more efficiently with plain leucine than with a full BCAA supplement because leucine absorbs faster, causing leucine levels in the blood to rise quickly and dramatically. The more leucine there is to go around, the more protein synthesis can occur, theoretically.
Muscle Growth
Leucine's effect on protein synthesis is 10 times greater than that of any other amino acid, according to nutritionist and bodybuilder Layne Norton. When you lift weights, it causes damage that breaks down your muscles. As protein synthesis occurs, not only do your muscles repair themselves, but they steel themselves for the next onslaught of abuse by making your muscle cells larger. When this occurs frequently over time, the evidence is seen as muscle growth. Leucine's job is to keep your muscles from breaking down, but then to allow them to rebuild at the same rate or more than they would have anyway. In other words, your muscles will rebuild at least the usual amount, but they won't have to compensate for muscle damage at the beginning of the process. This means that all growth that occurs would contribute to increased size.
Fat Loss
Leucine has also been explored as a fat-loss drug. When you restrict your calories, some of the weight you lose can come from muscle mass, which can slow your progress. Muscle requires energy to exist, so it burns calories, even when you're sitting still. Fat is just dead weight. So ideally, you want to hold on to as much muscle as possible while shedding fat only. Exercise helps with this, but leucine supplementation may help your muscle survive the calorie restriction better by providing an environment and ingredients for muscle growth. It may also play a role in reducing hunger and fatigue by stabilizing glucose levels. A 2003 study in the Journal of Nutrition concluded that BCAAs, but especially leucine, could play a beneficial role in weight-loss programs.
Food Sources
Branched-chain amino acids make up about 15 to 25 percent of the protein you eat. If you eat a balanced diet and consistently get enough protein, a supplement may be unnecessary for you. Animal proteins are complete proteins, meaning they provide all the essential amino acids. Meat, poultry and dairy are especially high in leucine. Vegetarians must eat a variety of foods to get all of the amino acids, but soy, lentils and peanuts are all high in leucine; in fact, soy and lentils contain more leucine than beef.
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